GFMER Global Consultation on WHO Infertility Guidelines
EWG: IVF, ICSI
Chair: André van Steirteghem (Belgium)
Members
- John Collins (Canada)
- Arne Sunde (Norway)
- Laura Francesca Rienzi (Italy)
- Catherine Racowsky (USA)
- Andy LaBarbera (USA)
Participants
- Adrián Villegas Cisneros - Institute of Science in Human Reproduction Vida, Guadalajara, Mexico
- Amit Bansal - NeuroCognitive Imaging Lab, Dalhousie University, Canada
- Elwassiela Salih Abdalla Mohammed - Obstetrics and Gynaecology Department, College of Medicine, Taif University, Saudi Arabia
- Euzebus Chinonye Ezugwu - Department of Obstetrics and Gynecology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria
- Faisal Al-Maslami - Dr. Sulaiman Al-Habib Medical Group, Al-Qassim Hospital, Saudi Arabia
- Farah Shakur - Edinburgh Fertility and Reproductive Endocrine Centre, Edinburgh Royal Infirmary, United Kingdom
- Forough Radfar - Khoula Hospital, Muscat, Oman
- Karpagambal Sairam - Mehta Hospital, Chennai, India
- Nilowfar Sultany - Malalay Maternity Hospital, Kabul, Afghanistan
- Rudolph Kantum Adageba - Komfo Anokye Teaching Hospital, Kumasi, Ghana
- Tahira Kazmi - Rustaq Hospital, Ministry of Health, Oman
- Tin Tin Thein - Department of Medical Research, Upper Myanmar, Myanmar
- Uchenna Nwagha - Department of Medical Physiology/Obstetrics and Gynaecology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria
- Zi-Jiang Chen - Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, China
WHO DRAFT PICO Questions:
Population Intervention Comparator Outcome (PICO):
Being developed to find the evidence in order to determine if a Recommendation on best practice can be made by the World Health Organization concerning the following topic.
IVF/ICSI
(P = women and men of reproductive age – questions may include exclusion or inclusion criteria)
Should WHO develop a recommendation concerning:
- the efficacy for the two most frequently used media systems for human embryo culture: sequential media versus single step media?
- whether culturing human embryos in low oxygen tension increases implantation potential and developmental competence?
- the efficacy for culturing human embryos singly or in groups?
- which single or combined parameters could be used to predict embryo competence.
- whether the day of transfer (i.e. duration of culture) can increase the efficiency of IVF/ICSI and reduce risks (multiple pregnancy).
- whether the number of embryos transferred can be individualized to optimize the balance between efficiency (pregnancy per transfer) and risks (multiple pregnancy)?
- whether assisted hatching of human embryos increases the probability of live birth?
- whether ICSI should be used routinely in couples with no evidence of male infertility?
- whether ICSI improves pregnancy rates and live birth rates in IVF for couples with unexplained infertility?
- whether ICSI improves pregnancy rates and live birth rates in IVF where the male partner is undergoing testicular sperm retrieval?
- whether ICSI improves pregnancy rates and live birth rates in IVF cycles with PGD, PGS or IVM?
- whether ICSI improves pregnancy rates and live birth rates in IVF cycles for couples with prior failed fertilization or expected low fertilization?
- whether ICSI improves pregnancy rates or live birth rates in IVF cycles for couples where the female partner has a low oocyte yield or advanced maternal age?
- whether ICSI improves pregnancy rates or live birth rates in IVF cycles with cryopreserved oocytes?
- whether single embryo transfer with cryopreservation of supernumerary embryos yields higher overall pregnancy rates and live birth rates compared with transfer of multiple fresh embryos?
- whether vitrification/warming of embryos yields superior embryo survival, pregnancy rates and live birth rates compared with slow freezing/thawing?
- whether vitrification/warming of mature oocytes yields superior embryo survival, pregnancy rates and live birth rates compared with slow freezing/thawing?
- whether vitrification/warming of donor oocytes yields superior embryo survival, pregnancy rates and live birth rates compared with slow freezing/thawing?