Community genetics - Course files - Training Course in Sexual and Reproductive Health Research 2013

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Community genetics - Course files

Course file - Author(s)	References, relevant online documents and resources
Principles of human genetics
Introduction to the module of community genetics - Hanan Hamamy	WHO. Community genetics services: report of a WHO consultation on community genetics in low- and middle-income countries. Geneva: WHO; 2010.
Introduction to basic human genetics - Hanan Hamamy	ten Kate LP. Genetic risk. J Community Genet. 2012 Jul;3(3):159–66. WHO. Birth defects. Report by the Secretariat. Geneva: WHO; 2010.
Unifactorial or single gene disorders - Hanan Hamamy	GeneTests Genome.gov \| Talking Glossary: "Recessive" Illustrated Glossary -- GeneReviews -- NCBI Bookshelf Mechanisms of Inheritance OMIM - Online Mendelian Inheritance in Man What are the different ways in which a genetic condition can be inherited? - Genetics Home Reference
Medical family history: tools for your practice - National Coalition for Health Professional Education in Genetics, National Society of Genetic Counselors	National Coalition for Health Professional Education in Genetics National Society of Genetic Counselors Print version of the Core Principles in Family History and the Core Principles in Family History Quick Facts
Basic human genetics: reproductive health and chromosome abnormalities - Hanan Hamamy	Down syndrome: prenatal screening and diagnosis : Guidelines, reviews Sex differentiation disorders : Guidelines, reviews
Cytogenetics, chromosomal genetics - Sophie Dahoun	Chromosomal Banding - Chromosome Banding Techniques
Multifactorial or polygenic inheritance - Hanan Hamamy	McCarthy M, Menzel S. The genetics of type 2 diabetes. Br J Clin Pharmacol. 2001 Mar;51(3):195–9.
Examples of pedigrees - Hanan Hamamy

Principles of genetic counseling
Genetic counseling - Hanan Hamamy	Forrest LE, Delatycki MB, Skene L, Aitken M. Communicating genetic information in families--a review of guidelines and position papers. Eur. J. Hum. Genet. 2007 Jun;15(6):612-8. Rantanen E, Hietala M, Kristoffersson U, Nippert I, Schmidtke J, Sequeiros J, Kääriäinen H. Regulations and practices of genetic counselling in 38 European countries: the perspective of national representatives. Eur. J. Hum. Genet. 2008 Oct;16(10):1208-16. Rantanen E, Hietala M, Kristoffersson U, Nippert I, Schmidtke J, Sequeiros J, Kääriäinen H. What is ideal genetic counselling? A survey of current international guidelines. Eur. J. Hum. Genet. 2008 Apr;16(4):445-52.
Ethical issues in medical genetics and genetic services - Hanan Hamamy	Borry P, Evers-Kiebooms G, Cornel MC, Clarke A, Dierickx K. Genetic testing in asymptomatic minors: background considerations towards ESHG Recommendations. Eur. J. Hum. Genet. 2009 Jun;17(6):711-9. WHO. Proposed International Guidelines on Ethical Issues in Medical Genetics and Genetic Services. Report of WHO Meeting. Geneva: WHO; 1998. WHO. Review of ethical issues in medical genetics. Geneva: WHO; 2003.
Consanguineous marriages. Trends, impact on health and counseling - Hanan Hamamy	Bittles AH, Black ML. Evolution in health and medicine Sackler colloquium: Consanguinity, human evolution, and complex diseases. Proc. Natl. Acad. Sci. U.S.A. 2010 Jan 26;107 Suppl 11779-86. Tadmouri GO, Nair P, Obeid T, Al Ali MT, Al Khaja N, Hamamy HA. Consanguinity and reproductive health among Arabs. Reprod Health. 2009;617. Al-Gazali L, Hamamy H, Al-Arrayad S. Genetic disorders in the Arab world. BMJ. 2006 Oct 21;333(7573):831-4. Hamamy H, Alwan A. Hereditary disorders in the Eastern Mediterranean Region. Bull. World Health Organ. 1994;72(1):145-54. Shami SA, Schmitt LH, Bittles AH. Consanguinity related prenatal and postnatal mortality of the populations of seven Pakistani Punjab cities. J. Med. Genet. 1989 Apr;26(4):267-71. Devi AR, Rao NA, Bittles AH. Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India. J. Med. Genet. 1987 Jun;24(6):362-5.
Principles of population genetics - Leo P ten Kate	European Society of Human Genetics. Population genetic screening programmes: technical, social and ethical issues. Eur. J. Hum. Genet. 2003 Dec;11(12):903-5. Godard B, ten Kate L, Evers-Kiebooms G, Aymé S. Population genetic screening programmes: principles, techniques, practices, and policies. Eur. J. Hum. Genet. 2003 Dec;11 Suppl 2S49-87.
Applications in population genetics - Hanan Hamamy
Prenatal genetic screening and diagnosis - Hanan Hamamy	Wieacker P, Steinhard J. The prenatal diagnosis of genetic diseases. Dtsch Arztebl Int. 2010 Dec;107(48):857–62.
Basic concepts in dysmorphology - Samia Temtamy, Mona Aglan	London Medical Databases OMIM - Online Mendelian Inheritance in Man POSSUM Web

Prevention strategies and research
Community genetics - Hanan Hamamy	Hamamy H, Al-Hait S, Alwan A. Strategies for low and medium resource countries in the community care and prevention of birth defects: Jordan model. A proposal for a national strategy on the care and prevention of birth defects in Jordan. Geneva Foundation for Medical Education and Research. 2009 Aug 27. Ten Kate LP, Al-Gazali L, Anand S, Bittles A, Cassiman J, Christianson A, Cornel MC, Hamamy H, Kääriäinen H, Kristoffersson U, Marais D, Penchaszadeh VB, Rahman P, Schmidtke J. Community genetics. Its definition 2010. J Community Genet. 2010 Mar;1(1):19-22.
Primary prevention of congenital disorders - Hanan Hamamy	Bennett RL. The family medical history as a tool in preconception consultation. J Community Genet. 2012 Jul;3(3):175-83. De Wert GM, Dondorp WJ, Knoppers BM. Preconception care and genetic risk: ethical issues. J Community Genet. 2012 Jul;3(3):221-8.
Periconception care and primary prevention of neural-tube defects and other congenital abnormalities by periconceptional folic acid/ multivitamin supplementation - Andrew Czeizel	Blencowe H, Cousens S, Modell B, Lawn J. Folic acid to reduce neonatal mortality from neural tube disorders. Int J Epidemiol. 2010 Apr;39 Suppl 1:i110-21. Polifka JE, Friedman JM. Medical genetics: 1. Clinical teratology in the age of genomics. CMAJ. 2002 Aug 6;167(3):265–73. The Teratology Society. Teratology Primer, Second Edition. 2010.
Epidemiology, care and prevention of hemoglobinopathies - Nasir Al-Allawi	Kleanthous M. Thalassemia prevention: screening and prenatal diagnostic approaches. Paper presented at: Training Course in Sexual and Reproductive Health Research; 2011 Nov 18; Geneva. Al-Allawi NA, Al-Dousky AA. Frequency of haemoglobinopathies at premarital health screening in Dohuk, Iraq: implications for a regional prevention programme. East Mediterr Health J. 2010 Apr;16(4):381-5. Modell B, Darlison M. Global epidemiology of haemoglobin disorders and derived service indicators. Bull World Health Organ. 2008 Jun;86(6):480-7. WHO. Management of haemoglobin disorders: report of a joint WHO-TIF meeting, Nicosia, Cyprus, 16–18 November 2007. Geneva: World Health Organization, 2008. Thalassaemia International Federation
Sickle cell disease: introduction - Hanan Hamamy	WHO. Sickle-cell disease and other haemoglobin disorders. Geneva: WHO; 2011. WHO Regional Office for Africa. Sickle cell disease: a strategy for the WHO African region. WHO Regional Office for Africa: Malabo; 2010.
Rational for birth defect registry, surveillance and monitoring based on the Hungarian experiences - Andrew Czeizel	Czeizel A. Self-poisoning during pregnancy as a model for teratogenic risk estimation of drugs. Disaster epidemiology. Paper presented at: Training Course in Sexual and Reproductive Health Research; 2011 Nov 18; Geneva. Mulvihill JJ. Preconception exposure to mutagens: medical and other exposures to radiation and chemicals. J Community Genet. 2012 Jul;3(3):205-11.
Research priorities in integrating community genetic services in primary care settings - Hanan Hamamy	Khoshnood B, Greenlees R, Loane M, Dolk H. Paper 2: EUROCAT public health indicators for congenital anomalies in Europe. Birth Defects Res Part A Clin Mol Teratol. 2011 Mar;91 Suppl 1S16–22.
Scientific research. Writing for publication: steps for novice writers - Hanan Hamamy	ICMJE: Uniform Requirements for Manuscripts Submitted to Biomedical Journals