TABLE 2. Clinicopathologic presentation of complete and partial mole.
|
Complete mole |
Partial mole |
|
|
Symptoms |
Spontaneous abortion of 2nd trimester Uterus large for date Heavy bleeding Preeclampsia |
Spontaneous abortion of 1st trimester Uterus small for date Moderate bleeding
|
|
Gross |
Generalized villous swelling, without fetus cord, or amniotic membranes |
Partial villous swelling with fetus cord, and/or amniotic membranes |
|
Histology |
Trophoblastic hyperplasia often marked, associated with atypia. Absence of fetal vessels |
Slight focal trophoblastic hyperplasia with rare atypia. Presence of fetal vessels. |
|
Cytogenetics |
46,XX (biandrogenetic: all paternal) |
69,XXY or 69,XXX (triploidy) |
|
PGTD |
Approximately 20% |
Approximately 5% |
|
Choriocarcinoma |
2 to 3% |
Not reported |