TABLE 1. Etiological factors in premature ovarian failure.
Congenital defects | Reduced number of germ cells |
Increased follicular atresia | |
X chromosome alterations | |
Enzymatic alterations | 17a -hydroxylase deficiency |
Galactosemia | |
Gonadotropin secretion alterations | Secretion of biological inactive forms |
α or ß subunit defects | |
Gonadotropin receptor alterations | Resistant ovary syndrome (Savage syndrome) |
Autoimmune disorders | Isolated |
Associated with other endocrine disorders | |
Iatrogenic causes | Radiotherapy |
Chemotherapy | |
Ovariectomy | |
Infectious causes | Viral agents |
Idiopathic |